Kreutzer, Adam G. published the artcileStabilization, Assembly, and Toxicity of Trimers Derived from Aβ, Category: ethers-buliding-blocks, the publication is Journal of the American Chemical Society (2017), 139(2), 966-975, database is CAplus and MEDLINE.
Oligomers of the β-amyloid peptide Aβ have emerged as important contributors to neurodegeneration in Alzheimer’s disease. Mounting evidence suggests that Aβ trimers and higher-order oligomers derived from trimers have special significance in the early stages of Alzheimer’s disease. Elucidating the structures of these trimers and higher-order oligomers is paramount for understanding their role in neurodegeneration. This paper describes the design, synthesis, X-ray crystallog. structures, and biophys. and biol. properties of two stabilized trimers derived from the central and C-terminal regions of Aβ. These triangular trimers are stabilized through three disulfide crosslinks between the monomer subunits. The X-ray crystallog. structures reveal that the stabilized trimers assemble hierarchically to form hexamers, dodecamers, and annular pore-like structures. Solution-phase biophys. studies reveal that the stabilized trimers assemble in solution to form oligomers that recapitulate some of the higher-order assemblies observed crystallog. The stabilized trimers share many of the biol. characteristics of oligomers of full-length Aβ, including toxicity toward a neuronally derived human cell line, activation of caspase-3 mediated apoptosis, and reactivity with the oligomer-specific antibody A11. These studies support the biol. significance of the triangular trimer assembly of Aβ β-hairpins and may offer a deeper understanding of the mol. basis of Alzheimer’s disease.
Journal of the American Chemical Society published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Category: ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem