Adriani, John published the artcileThe comparative potency and effectiveness of topical anesthetics in man, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Clinical Pharmacology & Therapeutics (New York, NY, United States) (1964), 49-62, database is CAplus and MEDLINE.
A technique with the use of elec. stimulation was developed. The tip of the tongue is the most sensitive area in the body to this type of stimulation. Over 40 drugs with topical activity were studied with the tip of the tongue as the test site. The most potent and effective compounds are tetracaine, cocaine, dibucaine, lidocaine, and dyclonine (I). With exception of I, these are toxic systemically if used in excess. The addition of vasoconstrictors, detergents, demulcents, cations, hyaluronidase, and other often-suggested potentiating agents does extend the period of activity.
Clinical Pharmacology & Therapeutics (New York, NY, United States) published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem