Young, Trudye A. published the artcileA pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients, COA of Formula: C17H28ClNO3, the publication is Journal of Dermatological Treatment (2009), 20(2), 76-81, database is CAplus and MEDLINE.
Objective: The objective of this study was to evaluate the efficacy of a com. available anti-itch lotion containing 1% pramoxine hydrochloride vs. control lotion in the treatment of uremic pruritus in adult hemodialysis patients. Methods: This was a randomized, double-blind, controlled comparative trial set in a community hemodialysis center. The study population comprised 28 individuals (mean age 53.5) with moderate to severe uremic pruritus who had been receiving hemodialysis for at least 3 mo. All participants were recruited from one community hemodialysis center. Topical anti-itch lotion containing 1% pramoxine was applied twice daily to all affected areas of pruritus for 4 wk. The main outcome measure was a reduction in itch intensity. Secondary outcomes included increases in the investigator’s global assessment and improvement in skin hydration. Results: There was a 61% decrease in itch intensity in the treatment group, whereas a 12% reduction in itch intensity was observed in the control group. The rate of decline in itching was also greater in the treatment arm vs. the control arm. No significant differences were displayed in other studied disease-related variables. Conclusion: Our study shows that individuals using pramoxine 1% lotion experienced a reduction in pruritus to a greater degree than those using the control lotion. This safe, convenient and effective topical lotion may potentially benefit the large number of patients affected by pruritus associated with end-stage renal disease.
Journal of Dermatological Treatment published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C6H17NO3Si, COA of Formula: C17H28ClNO3.
Referemce:
https://en.wikipedia.org/wiki/Ether,
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