Wipf, Peter published the artcileSynthesis and Biological Evaluation of Structurally Highly Modified Analogues of the Antimitotic Natural Product Curacin A, Computed Properties of 99438-28-5, the publication is Journal of Medicinal Chemistry (2002), 45(9), 1901-1917, database is CAplus and MEDLINE.
Structure-activity relationship anal. of synthetic analogs of curacin A revealed the lack of activity of traditional heterocyclic replacements of the thiazoline ring or cyclopropyl analogs of the core diene segment. The significance of the C(3)-C(4)-(Z)-alkene geometry was established, and a novel oxime analog was designed that displays biol. properties that are a close match of the natural product lead. The much less lipophilic, structurally simplified oxime I was only slightly weaker at inhibiting the growth of cultured human tumor cells than the natural product and was found to be more potent than curacin A at inhibiting the assembly of purified tubulin. Accordingly, the oxime moiety is likely to serve as a novel bioisostere of the (Z)-alkene group.
Journal of Medicinal Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C3H6O2, Computed Properties of 99438-28-5.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem