Stolze, Sara C. published the artcileDevelopment of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing Cyclodepsipeptides, Safety of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is European Journal of Organic Chemistry (2012), 2012(8), 1616-1625, S1616/1-S1616/32, database is CAplus.
The 3-amino-6-hydroxy-2-piperidone (Ahp) containing cyclodepsipeptides are an interesting class of natural products that inhibit S1 (trypsin and chymotrypsin-like) serine protease in a reversible, noncovalent manner, turning them into potential chem. tools for protease research. Their systematic use in chem. biol. is however hampered by their tedious solution-phase chem. synthesis. To overcome this limitation, the authors report a solid-phase approach to Ahp cyclodepsipeptides that is based on the use of a masked glutamic aldehyde moiety as a general Ahp precursor mol. As a proof-of-concept, the authors therefore recently reported the solid-phase synthesis of symplocamide A. Here, the authors want to give a full account on the development and application of the masked glutamic aldehyde moiety as well as the optimization of the solid-phase synthesis, which allowed the successful synthesis of the natural product symplocamide A.
European Journal of Organic Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C4Br2N2O4S, Safety of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem