Sakya, Subas M. published the artcileEfficient synthesis of 5-alkyl amino and thioether substituted pyrazoles, Synthetic Route of 52818-63-0, the publication is Tetrahedron Letters (2003), 44(41), 7629-7632, database is CAplus.
Nucleophilic substitution reactions of 1-(4-methylsulfonyl-2-pyridyl)-5-chloro pyrazoles with various substitutions at the 4 position with amine nucleophiles and thiols occur under mild conditions to provide the 5-alkylamino and thioether pyrazoles in high yields. Reaction products of 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxaldehyde with piperazine derivatives, benzenethiol, 1H-imidazole, cyclohexanethiol, 2(1H)-pyridinethione, etc. were reported. A similar reaction of 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile, 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid Me ester and 4-chloro-1-[5-(methylsulfonyl)-2-pyridinyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide with amines was also reported.
Tetrahedron Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Synthetic Route of 52818-63-0.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem