Fukuda, Hayato published the artcileSynthesis and Structure-Activity Relationship of Vicenistatin, a Cytotoxic 20-Membered Macrolactam Glycoside, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Chemistry – An Asian Journal (2012), 7(12), 2872-2881, S2872/1-S2872/34, database is CAplus and MEDLINE.
We have developed two syntheses of viceniqstatin and its analogs. Our first-generation strategy included the rapid and sequential assembly of the macrocyclic lactam by using an intermol. Horner-Wadsworth-Emmons reaction between the C3-C13 fragment and the C1-C2, C14-C19 fragment, followed by an intramol. Stille coupling reaction. The second-generation strategy utilized a ring-closing metathesis of a hexa-ene intermediate to generate the desired 20-membered macrolactam. This second-generation strategy made it possible to prepare synthetic analogs of vicenistatin, including the C20- and/or C23-demethyl analogs. Evaluation of the cytotoxic effect of these analogs indicated the importance of the fixed conformation of aglycon for determining the biol. activity of the vicenistatins.
Chemistry – An Asian Journal published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem