Dalai, Pallaba Ganjan published the artcileGeneration of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation, Application In Synthesis of 93-04-9, the publication is Advanced Synthesis & Catalysis (2022), 364(5), 1031-1038, database is CAplus.
A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions.
Advanced Synthesis & Catalysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Application In Synthesis of 93-04-9.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem