Varela-Aramburu, Silvia published the artcileIntroducing Hyaluronic Acid into Supramolecular Polymers and Hydrogels, Synthetic Route of 23783-42-8, the main research area is hyaluronic acid supramol polymer hydrogel functional biomaterial.
The use of supramol. polymers to construct functional biomaterials is gaining more attention due to the tunable dynamic behavior and fibrous structures of supramol. polymers, which resemble those found in natural systems, such as the extracellular matrix. Nevertheless, to obtain a biomaterial capable of mimicking native systems, complex biomols. should be incorporated, as they allow one to achieve essential biol. processes. In this study, supramol. polymers based on water-soluble benzene-1,3,5-tricarboxamides (BTAs) were assembled in the presence of hyaluronic acid (HA) both in solution and hydrogel states. The coassembly of BTAs bearing tetra(ethylene glycol) at the periphery (BTA-OEG4) and HA at different ratios showed strong interactions between the two components that led to the formation of short fibers and heterogeneous hydrogels. BTAs were further covalently linked to HA (HA-BTA), resulting in a polymer that was unable to assemble into fibers or form hydrogels due to the high hydrophilicity of HA. However, coassembly of HA-BTA with BTA-OEG4 resulted in the formation of long fibers, similar to those formed by BTA-OEG4 alone, and hydrogels were produced with tunable stiffness ranging from 250 to 700 Pa, which is 10-fold higher than that of hydrogels assembled with only BTA-OEG4. Further coassembly of BTA-OEG4 fibers with other polysaccharides showed that except for dextran, all polysaccharides studied interacted with BTA-OEG4 fibers. The possibility of incorporating polysaccharides into BTA-based materials paves the way for the creation of dynamic complex biomaterials.
Biomacromolecules published new progress about Crosslinking. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Synthetic Route of 23783-42-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem