Jiang, Meiyu published the artcileSelf-assembly of Amphiphilic Porphyrins To Construct Nanoparticles for Highly Efficient Photodynamic Therapy, Application In Synthesis of 23783-42-8, the main research area is amphiphilic porphyrin preparation PDT cancer nanoparticle; amphiphilic; nanoparticles; photodynamic therapy; self-assembly; triphenylphosphine.
Hydrophobic photosensitizers greatly affect cell permeability and enrichment in tumors, but they cannot be used directly for clin. applications because they always aggregate in water, preventing their circulation in the blood and accumulation in tumor cells. As a result, amphiphilic photosensitizers are highly desirable. Although nanomaterial-based photosensitizers can solve water solubility, they have the disadvantages of complicated operation, poor reproducibility, low drug loading, and poor stability. In this work, an efficient synthesis strategy is proposed that converts small mols. into nanoparticles in 100% aqueous solution by mol. assembly without the addition of any foreign species. Three photosensitizers with triphenylphosphine units and ethylene glycol chains of different lengths, TPP-PPh3, TPP-PPh3-2PEG and TPP-PPh3-4PEG, were synthesized to improve amphiphilicity. Of the three photosensitizers, TPP-PPh3-4PEG is the most efficient (singlet oxygen yield: 0.89) for tumor photodynamic therapy not only because of its definite constituent, but also because its amphiphilic structure allows it to self-assemble in water.
Chemistry – A European Journal published new progress about Amphiphiles. 23783-42-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11-Tetraoxatridecan-13-ol, and the molecular formula is C9H20O5, Application In Synthesis of 23783-42-8.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem