Glennon, Richard A. published the artcileIdentification and exploitation of the σ-opiate pharmacophore, Formula: C8H9ClO, the main research area is alkylation reduction phenylpropylamine; amine alkylmethylphenylethyl sigma receptor; benzeneethanamine alkylmethyl psychotomimetic sigma receptor; benzomorphan receptor binding; phenylpropylamine alkyl psychotomimetic sigma receptor; reduction alkylation phenylpropylamine; psychotomimetic sigma receptor phenylpropylamine alkyl; sigma receptor psychotomimetic phenylpropylamine alkyl; structure activity phenylpropylamine benzomorphan.
Reductive alkylation of PhCH2CH(NH2)Me gave (R)- and (S)-RR1NCHMeCH2Ph [I; R = Et, Pr, Bu, CH2Ph, CHMePh, CH2CH2Ph, (CH2)3Ph, (CH2)4Ph, (CH2)5Ph, C:CHPh, CH2OPh, etc.; R1 = H, Me]. E.g., alkylation of (R)-PhCH2CH(NH2)Me with PhCH2CH2CHO gave (R)-PhCH2CH2CH2NHCHMeCH2Ph. I were tested for their affinity to σ-receptors and their psychotomimetic activity; the structure-activity relationship was discussed. The role of I as a component of a benzomorphan structure was studied; the presence of a 1-phenyl-2-aminopropane nucleus was sufficient for binding at the σ-site, provided that the terminal amine is not a tertiary amine.
Journal of Medicinal Chemistry published new progress about Psychotomimetics. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Formula: C8H9ClO.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem