Demuner, Antonio Jacinto published the artcileThe Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain, SDS of cas: 127972-00-3, the main research area is Alternaria phytotoxin alternariol methyl ether analog preparation inhibition photosynthesis.
Alternariol and monomethylalternariol are natural phytotoxins produced by some fungal strains, such as Nimbya and Alternaria. These substances confer virulence to phytopathogens, yet no information is available concerning their mode of action. Here it is shown that in the micromolar range alternariol 9-Me ether is able to inhibit the electron transport chain (IC50 = 29.1 ± 6.5 μM) in isolated spinach chloroplasts. Since its effectiveness is limited by poor solubility in water, several alternariol analogs were synthesized using different aromatic aldehydes. The synthesized 6H-benzo-[c]-cromen-6-ones, 5H-chromene-[4,3-b]-pyridin-5-one, and 5H-chromene-[4,3-c]-pyridin-5-one also showed inhibitory properties, and three 6H-benzo-[c]-cromen-6-ones were more effective (IC50 = 12.8-22.8 μM) than the lead compound Their addition to the culture medium of a cyanobacterial model strain was found to inhibit algal growth, with a relative effectiveness that was consistent with their activity in vitro. In contrast, the growth of a nonphotosynthetic plant cell culture was poorly affected. These compounds may represent a novel lead for the development of new active principles targeting photosynthesis.
Journal of Natural Products published new progress about Alternaria. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem