Yu, Xiaochun published the artcilePalladium-Catalyzed N-Alkylation of Amides and Amines with Alcohols Employing the Aerobic Relay Race Methodology, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Chinese Journal of Chemistry (2012), 30(10), 2322-2332, database is CAplus.
Possibly because homogeneous palladium catalysts are not typically borrowing hydrogen catalysts and ligands are thus ineffective in catalyst activation under conventional anaerobic conditions, they had not been used in the N-alkylation reactions of amines/amides with alcs. in the past. By employing the aerobic relay race method with Pd-catalyzed aerobic alc. oxidation being a more effective protocol for alc. activation, ligand-free homogeneous palladium are successfully used as active catalysts in the dehydration N-alkylation reactions, giving high yields and selectivities of the alkylated amides and amines. Mechanistic studies implied that the reaction most probably proceeds by a novel relay race mechanism that was recently discovered and proposed.
Chinese Journal of Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C9H6BrNO, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem