Yan, Xiao-Biao published the artcileNi-catalyzed hydroalkylation of olefins with N-sulfonyl amines, Formula: C8H11NO, the publication is Nature Communications (2021), 12(1), 5881, database is CAplus and MEDLINE.
Herein, a reliable method for accessing α-branched amines RNHCH(R1)(CH2)2R2 (R = (4-methylphenyl)sulfonyl, (2,4,6-trimethylphenyl)sulfonyl; R1 = Ph, 4-morpholinophenyl, furan-2-yl, etc.; R2 = Ph, 3-fluorophenyl, 9H-fluoren-2-yl, etc.) via nickel-catalyzed hydroalkylation reactions was reported. Specifically, by using bis(cyclooctadiene)nickel (Ni(cod)2) together with a phosphine ligand, a formal C(sp3)-H bond insertion reaction between olefins CH2=CHR2 and N-sulfonyl amines RNHCH2R1 without the need for an external hydride source was achieved. The amine not only provides the alkyl motif but also delivers hydride to the olefin by means of a nickel-engaged β-hydride elimination/reductive elimination process. This method provides a platform for constructing chiral α-branched amines (R/S)-RNHCH(R1)CH2CH2R2 by using a P-chiral ligand, demonstrating its potential utility in organic synthesis. Notably, a sulfonamidyl boronate complex formed in situ under basic conditions promotes ring-opening of the azanickellacycle reaction intermediate, leading to a significant improvement of the catalytic efficiency.
Nature Communications published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C19H15NO3, Formula: C8H11NO.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem