Singh, Sanjay published the artcileDevelopment of Transition-Metal-Free Lewis Acid-Initiated Double Arylation of Aldehyde: A Facile Approach Towards the Total Synthesis of Anti-Breast-Cancer Agent, Recommanded Product: 1,2-Dimethoxybenzene, the publication is Chemistry – A European Journal (2022), 28(14), e202104545, database is CAplus and MEDLINE.
This work describes a mild and robust double hydroarylation strategy for the synthesis of sym. /unsym. diaryl- and triarylmethanes in excellent yields using Lambert salt (0.2-1.0 mol%). Despite the anticipated challenges associated with controlling selective product formation, unsym. diaryl- and triarylmethanes products are obtained unprecedentedly. A highly efficient gram scale reaction has also been reported (TON for sym. product=475 and for unsym. product=390). The synthetic utility of the methodol. is demonstrated by the preparation of several unexplored diaryl- and triarylmethane-based biol. relevant mols., such as arundine, vibrindole A, turbomycin B, and certain anti-inflammatory agents. A total synthesis of an anti-breast-cancer agent is also demonstrated. Control experiments, Hammett anal., HRMS and GC-MS studies reveal the reaction intermediates and reaction mechanism.
Chemistry – A European Journal published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C13H18BBrO3, Recommanded Product: 1,2-Dimethoxybenzene.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem