Phelan, James P. published the artcileOpen-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis, Formula: C25H23NO4, the publication is Journal of the American Chemical Society (2019), 141(8), 3723-3732, database is CAplus and MEDLINE.
DNA-encoded library (DEL) technol. is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomol. targets. Success in this endeavor lies in sampling diverse chem. libraries. However, current DELs tend to be deficient in C(sp3) carbon counts. The authors report unique solutions to the challenge of increasing both the chem. diversity of these libraries and their C(sp3) carbon counts by merging Ni/photoredox dual catalytic C(sp2)-C(sp3) cross-coupling as well as photoredox-catalyzed radical/polar crossover alkylation protocols with DELs. The successful integration of multiple classes of radical sources enables the rapid incorporation of a diverse set of alkyl fragments.
Journal of the American Chemical Society published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Formula: C25H23NO4.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem