Karelin, A. A. published the artcileInhibition of serum transamidinase by formamidine disulfide. Identification of the SH-group at the active site of the enzyme, Formula: C2H8Cl2N4S2, the publication is Biokhimiya (Moscow) (1972), 37(3), 652-5, database is CAplus and MEDLINE.
Formamidine disulfide (I) [14807-75-1] inhibited the activity of serum transamidinase (EC 2.1.4.1) [9027-35-4] from patients with pancreonecrosis by 50% at 10-6M and by 90% at 2.2 .tim. 10-6M. Preincubation of serum transamidinase with 1 μg trypsin [9002-07-7] increased the inhibitory effect of I. L-canavanine [543-38-4], an amidine donor which is the substrate of the reaction, efficiently protected the activity of the enzyme. Apparently, intactness of the substrate amidine binding region of the enzyme containing the essential sulfhydryl group is the main condition of the preservation of enzymic activity in the blood.
Biokhimiya (Moscow) published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Formula: C2H8Cl2N4S2.
Referemce:
https://en.wikipedia.org/wiki/Ether,
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