Chiba, Takuya published the artcileStructure-activity relationship study of syringolin A as a potential anticancer agent, HPLC of Formula: 77128-73-5, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(21), 4872-4877, database is CAplus and MEDLINE.
A detailed structure-activity relationship of syringolin, which is a promising antitumor natural product, was described. The authors previously developed syringolin A analog I as a potent proteasome inhibitor by the structure-based drug design of syringolin A. The authors synthesized a range of analogs of I, having a different length of the lipophilic chain and substituted aryl group, and their cytotoxicity against human cancer cells was evaluated. It turned out that these modifications greatly affected the cytotoxicity. Further optimization would lead to develop a novel proteasome inhibitor.
Bioorganic & Medicinal Chemistry Letters published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, HPLC of Formula: 77128-73-5.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem