Chadha, Vijay K. published the artcileInhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism, Product Details of C3H7NO2, the publication is Journal of Medicinal Chemistry (1983), 26(6), 916-22, database is CAplus and MEDLINE.
Sulfoxides and amides were tested as inhibitors of liver alc. dehydrogenase [9031-72-5] and of EtOH [64-17-5] metabolism in rats. With both series of compounds, increasing the hydrophobicity resulted in better inhibition, and introduction of polar groups reduced inhibition. Of the cyclic sulfoxides, tetramethylene sulfoxide (I) [1600-44-8] was the best inhibitor as compared to the tri- [13153-11-2] and pentamethylene analogs [4988-34-5] and other compounds, and it may be a transition-state analog. The most promising compounds, I and isovaleramide [541-46-8], were essentially uncompetitive inhibitors of purified horse and rat liver alc. dehydrogenases with respect to EtOH as substrate. These compounds also were uncompetitive inhibitors in vivo, which is advantageous since the inhibition is not overcome at higher concentrations of EtOH, as it is with competitive inhibitors, such as pyrazole. The uncompetitive inhibition constants for I and isovaleramide for rat liver alc. dehydrogenase were 200 and 20 μM, resp. in vitro, whereas in vivo the values were 340 and 180 μmol/kg, resp. The differences in the values may be due to metabolism or distribution of the compounds Further studies will be required to determine if isovaleramide or I is suitable for therapeutic purposes.
Journal of Medicinal Chemistry published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Product Details of C3H7NO2.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem