Yoshida, Masahito published the artcileSolid-phase combinatorial synthesis and biological evaluation of destruxin E analogs, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Chemistry – A European Journal (2015), 21(50), 18417-18430, database is CAplus and MEDLINE.
The solid-phase combinatorial synthesis of cyclodepsipeptide destruxin E has been demonstrated. The combinatorial synthesis of cyclization precursors was achieved by using a split and pool method on SynPhase Lanterns. The products were successfully macrolactonized in parallel in the solution phase by using 2-methyl-6-nitrobenzoic anhydride and 4-(dimethylamino)pyridine N-oxide to afford macrolactones, and the subsequent formation of an epoxide in the side chain gave 18 member destruxin E analogs. Biol. evaluation of the analogs indicated that the N-MeAla residue was crucial to the induction of morphol. changes in osteoclast-like multinuclear cells (OCLs). Based on structure-activity relationships, azido-containing analogs (I) [R1 = Me, R2 = (CH2)4N3, R3 = CH((S)-Me)CH2Me; R1 = Me, R2 = iso-Pr, R3 = (CH2)4N3; R1 = (CH2)4N3, R2 = iso-Pr, R3 = CH((S)-Me)CH2Me] were then designed for use as a mol. probe. The synthesis and biol. evaluation of analogs I revealed that I [R1 = Me, R2 = iso-Pr, R3 = (CH2)4N3], in which the Ile residue was replaced with a Lys(N3) residue, induced morphol. changes in OCLs at a sufficient concentration, and modification around the Ile residue would be tolerated for attachment of a chem. tag toward the target identification of destruxin E.
Chemistry – A European Journal published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C17H37NO3, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem