Vezina-Dawod, Simon published the artcileConvenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions, Application of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Tetrahedron (2017), 73(44), 6347-6355, database is CAplus.
A rapid and efficient two-step method was reported for synthesis of polysubstituted 1,4-benzodiazepin-3-ones I [R1 = t-Bu, (CH2)5, cyclohexyl, Bn; R2 = (CH2)3, Bn, Ph, etc.; R3 = H, Me, Bn, etc.; R4 = H, Me] and 1,5-benzodiazocin-4-ones II in high yields [R5 = H, Ph, 3-methyl-1H-indolyl] using a multicomponent condensation/cyclization. This approach used an Ugi four-component reaction to condense readily available N-Fmoc-amino acids, amines and isocyanides with a 2-fluoro-5-nitrobenzaldehyde to afford Fmoc-protected bis-amide intermediates, e.g., III followed by a one-pot Fmoc-group removal, intramol. aromatic nucleophilic substitution for ring closure and side chain deprotection.
Tetrahedron published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C12H16BNO4, Application of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem