Tavlarakis, Panagiotis published the artcileSimultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Analytical Methods (2010), 2(6), 722-727, database is CAplus.
A simple gradient reversed-phase high performance liquid chromatog. (HPLC) method was developed for the simultaneous determination of total benzalkonium chloride (BAC) and pramoxine HCl in wound care solutions Laboratory formulations were diluted 1:10 with water and injected into a HPLC system equipped with a Phenomenex, Luna CN column (100 Å, 5μm, 250 mm × 4.6 mm) in order for BAC and pramoxine to sep. from other excipients and be detected by a UV detector (λ = 262 nm). The mobile phase was 0.075 mM sodium acetate trihydrate buffer (pH = 5.0) using multi-ramp gradient elution with acetonitrile. Quantitation was achieved by direct comparison of the peaks of BAC and pramoxine HCl of the sample to a reference standard of known concentrations A stress study with acid, base, peroxide, heat, and light indicated no interference from drug product or excipients. The mean recovery results for both pramoxine and benzalkonium chloride at 100% level were 100.5 ± 0.3%, 100.5 ± 0.1% resp. (mean ± SD, n = 6). In this report, the full exptl. results from developing and validating this method are presented.
Analytical Methods published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H10O3S, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem