Pietrasiak, Ewa published the artcileCobalt-Catalyzed Formation of Grignard Reagents via C-O or C-S Bond Activation, Application In Synthesis of 93-04-9, the publication is Journal of Organic Chemistry (2022), 87(13), 8380-8389, database is CAplus and MEDLINE.
C(aryl)-OMe bond functionalization catalyzed by Co(II) chloride in combination with a nacnac-type ligand and Mg as a reductant is reported. Borylation and benzoylation of aryl methoxides are demonstrated, and C(aryl)-SMe bond borylation can be achieved under similar conditions. This is the 1st example of achieving these transformations using Co catalysis. Mechanistic studies suggest that a Grignard reagent is generated as an intermediate in a rare example of a magnesiation via a C-O bond activation reaction. Indeed, an organomagnesium species could be directly observed by electrospray ionization mass spectroscopic anal. Kinetic experiments indicate that a heterogeneous Co catalyst performs the C-O bond activation.
Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Application In Synthesis of 93-04-9.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem