Nakayama, Taku published the artcileWater-promoted dehydrative coupling of 2-aminopyridines in heptane via a borrowing hydrogen strategy, COA of Formula: C13H14N2O, the publication is RSC Advances (2021), 11(37), 23144-23150, database is CAplus and MEDLINE.
A synthetic method for dehydrative N-benzylation promoted by water mols. in heptane using a π-benzylpalladium system has been developed. The presence of water significantly accelerates carbon-nitrogen bond formation, which is accomplished in an atom-economical process to afford the corresponding N-monobenzylated products. A crossover experiment afforded H/D scrambled products, which is consistent with a borrowing hydrogen mechanism. Kinetic isotope effect measurements revealed that benzylic carbon-hydrogen bond cleavage was the rate-determining step.
RSC Advances published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, COA of Formula: C13H14N2O.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem