Ibrahim, Fawzia published the artcileComparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities, Formula: C17H28ClNO3, the publication is Journal of Food and Drug Analysis (2018), 26(3), 1160-1170, database is CAplus and MEDLINE.
In the present study, we compare the performance of two reversed-phase liquid chromatog. approaches using different eluents either conventional hydro-organic eluent or micellar one for simultaneous estimation of hydrocortisone acetate and pramoxine hydrochloride in presence of their degradants and process-related impurities; hydrocortisone and 4-butoxyphenol, resp. For conventional reversed-phase liquid chromatog. (RPLC), separation of the studied compounds was completed on an Inertsil ODS 3-C18 column (150 mm × 4.6 mm, 5μm particle size) with a mobile phase consists of 50 mM phosphate buffer (pH 5.0): acetonitrile (50: 50, volume/volume). For micellar liquid chromatog. (MLC), an Eclipse XDB-C8 column (150 mm × 4.6 mm, 5μm particle size) was chosen for the separation with a green mobile phase consists of 0.15 M sodium dodecyl sulfate, 0.3% triethylamine and 10% n-butanol in 20 mM orthophosphoric acid (pH 5.0). Both methods were extended to analyze hydrocortisone acetate and pramoxine hydrochloride in their co-formulated cream. RPLC was superior to MLC with regard to sensitivity for the estimation of impurities. While, MLC represents an eco-friendly, less hazardous and biodegradable approach. Furthermore, the direct injection of the cream to the system without the need to laborious samples pretreatment, excessive amount of anal. time and/or use of large amount of toxic organic solvents is one of the outstanding advantages of MLC.
Journal of Food and Drug Analysis published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Formula: C17H28ClNO3.
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