Yerien, Damian E. published the artcileRose Bengal-photocatalyzed perfluorohexylation reactions of organic substrates in water. Applications to late-stage syntheses, Application In Synthesis of 91-16-7, the publication is Photochemical & Photobiological Sciences (2022), 21(5), 803-812, database is CAplus and MEDLINE.
Rose Bengal-photocatalyzed perfluorohexylation of olefins, alkynes and electron-rich aromatic compounds in water was achieved employing perfluorohexyl iodide as fluoroalkyl source and TMEDA as sacrificial donor under green LED irradn to afford perfluoro compounds R1CHICH2C6F13 [R1 = CH2OPh, CHOH(CH2)5], R2HC=CHC6F13 [R2 = Ph, n-pentyl, (D)-(-)Norgestreyl] and I [R3 = 4-Me, 4-NO2, 2,6-(Me)2, etc.; R4 = OMe, NH2]. Alkenes and alkynes rendered products derived from the atom transfer radical addition (ATRA) pathway, and in the case of alkynes, exclusively as E-stereoisomers. These were the first examples of photocatalyzed ATRA reactions carried out excursively in water alone. The reactions of aromatic compounds under the current protocol in water present the advantage of employing a perfluoroalkyl iodide (C6F13-I) as source of perfluorohexyl radicals. Examples of photocatalytic late-stage incorporations of fluoroalkyl moieties into two com. drugs of widespread used were reported.
Photochemical & Photobiological Sciences published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C2H10Cl2N2, Application In Synthesis of 91-16-7.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem