Washington, Jack B. published the artcileTrialkylammonium salt degradation: implications for methylation and cross-coupling, Name: 2-Methoxynaphthalene, the publication is Chemical Science (2021), 12(20), 6949-6963, database is CAplus and MEDLINE.
This study presented a mechanistic degradation anal. of N,N,N-trimethylanilinium salts and highlighted implications for synthetic applications of this important class of salts. Kinetic degradation studies, in both solid and solution phases, had delivered insights into phys. and chem. parameters affecting anilinium salt stability. 1H NMR kinetic anal. of salt degradation had evidenced thermal degradation to Me iodide and parent aniline, consistent with a closed-shell SN2-centered degradative pathway, and Me iodide being key reactive species in applied methylation procedures. Furthermore, effect of halide and non-nucleophilic counterions on salt degradation had been investigated, along with deuterium isotope and solvent effects. New mechanistic insights had enabled investigation of use of trimethylanilinium salts in O-methylation and in improved cross-coupling strategies. Finally, detailed computational studies had helped highlight limitations in current state-of-the-art of solvation modeling of reaction in which bulk medium undergoes exptl. observable changes over reaction timecourse.
Chemical Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C14H10O4, Name: 2-Methoxynaphthalene.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem