Lei, Caiyu published the artcileMolecular hybridization of grape seed extract: Synthesis, structural characterization and anti-proliferative activity in vitro, Computed Properties of 121-00-6, the main research area is grape seed antiproliferative structural property; Anti-proliferation; Antioxidant; Grape seed extract; HepG2 cell; Hybridization.
The grape seed extract (GSE) hybridized with medium-chain saturated fatty acids (decanoic acid) exhibited higher lipophilicity, antioxidant activity, and anti-proliferative activity than its parents. The chem. structures of individual hybridized GSE derivatives were identified as 3′-O-decanoyl catechin, 3′-O-decanoyl epicatechin, 3′, 5′-2-O-decanoyl epigallocatechin, and 3′, 4′, 3”, 5”-4-O-decanoyl epicatechin gallate by HPLC-MS2 and 1H and 13C NMR. For growth inhibitory effect on HepG2 cells, hybridized GSE derivatives (EC50 = 44.38μg/mL) were significantly (p < 0.01) stronger than natural GSE (EC50 = 60.83μg/mL) due to increased lipophilicity. The effects of GSE derivatives on apoptosis and cell cycle in HepG2 cells were further evaluated by flow cytometry. The results showed that the percentage of apoptotic cells increased markedly in the presence of hybridized GSE derivatives Moreover, hybridized GSE derivatives were capable of inducing cell cycle arrest in G1 phase. This research suggests that hybridized GSE derivatives are effective lipophilic antioxidants and show the potential as adjuvant therapy for cancer. Food Research International published new progress about Grape. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Computed Properties of 121-00-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem