Astolfi, Paola published the artcileNew mediators for the enzyme laccase: mechanistic features and selectivity in the oxidation of non-phenolic substrates, Synthetic Route of 183303-74-4, the publication is New Journal of Chemistry (2005), 29(10), 1308-1317, database is CAplus.
New mediators of laccase have been comparatively evaluated and ranked towards the benchmark aerobic oxidation of p-MeO-benzyl alc. The mechanism of oxidation of this non-phenolic substrate by each mediator, which is initially oxidized by laccase to the Medox form, has been assessed among three alternatives. The latter make the phenoloxidase laccase competent for the indirect oxidation of non-phenolic (and thus unnatural) substrates. Exptl. characterization of the mediators, by spectrophotometric, electrochem. and thermochem. survey, is reported. Clear-cut evidence for the formation of a benzyl radical intermediate in the oxidation of a particular benzyl alc. with laccase and a :N-OH mediator is attained by a trapping experiment The selectivity of the laccase-catalyzed oxidation of two competing lignin and polysaccharide model compounds has been assessed by using the highly proficient 4-MeO-HPI mediator, and found very high in favor of the former model. This evidence is in keeping with the operation of a radical hydrogen-abstraction process that efficiently cleaves the benzylic rather than the aliphatic C-H bond of the two models. Significant is the finding that catechol, i.e., a model of recurring phenolic structures in lignin, once oxidized to aryloxyl radical by laccase is capable to mediate a radical oxidation of non-phenolic compounds This supports a fully-fledged role of laccase as a delignifying enzyme in nature by way of no other mediators than the very phenolic groups of lignin. Finally, an evaluation of the dissociation energy of the NO-H bond of HBT, which is not accessible exptl., is provided by the use of a thermochem. cycle and theor. calculations
New Journal of Chemistry published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C16H18O4, Synthetic Route of 183303-74-4.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem