Archibald, John L. published the artcileBenzamidopiperidines. 2. Heterocyclic compounds related to indoramin, Category: ethers-buliding-blocks, the publication is Journal of Medicinal Chemistry (1974), 17(7), 736-9, database is CAplus and MEDLINE.
A series of 19 title compounds prepared from 4-benzamidopiperidine [33953-37-6] by alkylation, acylation, Mannich or Michael-type reactions, or ring closure reactions were evaluated for hypotensive activity in anesthetized normotensive rats and antihypertensive activity in conscious renal hypertensive rats. The most active hypotensive compounds were I, R = 2-hydroxy-2-pyrrol-2-ylethyl [36793-50-7] and I, R = 2-(2-quinolyl)ethyl [36793-54-1]. The most active antihypertensive compounds were I, R = 2-(4-pyridyl)ethyl [36793-45-0], I, R = 2-(2-pyridyl)ethyl [36806-71-0], I, R = 2-(3-benzo[b]thienyl)ethyl [36793-52-9], and I, R = 2-(3-benz[g]indolyl)ethyl [36806-70-9]. None of the compounds were as potent as indoramin [26844-12-2] in either test. I, R = 2-phenothiazin-10-ylethyl [52818-64-1] caused noncompetitive antagonism of histamine in an isolated guinea-pig ileum preparation Structure-activity relations were discussed.
Journal of Medicinal Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Category: ethers-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem