Month: November 2022

Li, Sifeng; Wang, Zihao; Xiao, Haitao; Bian, Zhaoxiang; Wang, Jun published an article in 2020, the title of the article was Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

An efficient Rh/Pd relay catalyzed intermol. and cascade intramol. hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) I [R = n-Bu, 3-thienyl, phenyl; R1 = H, 5,8-di-Me, 5,8-di-MeO, etc.] was described under mild conditions. Moreover, the in-silico and in-vitro screening showed that the novel 1-indolyl dihydronaphthalenol products were potent lead compounds for treating inflammation disease. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to oxabenzonorbornadiene phenylethynyl aniline palladium rhodium tandem enantioselective diastereoselective hydroamination, indolyl dihydronaphthalenol preparation antiinflammatory mol docking and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 1, 2022, Sukowski, Verena; van Borselen, Manuela; Mathew, Simon; Fernandez-Ibanez, M. Angeles published an article.Application In Synthesis of 2-Methylanisole The title of the article was S,O-Ligand Promoted meta-C-H Arylation of Anisole Derivatives via Palladium/Norbornene Catalysis. And the article contained the following:

Here, a new catalytic system based on palladium/norbornene and an S,O-ligand for the meta-C-H arylation of aryl ethers that significantly outperforms previously reported systems has been developed. The unique ability of this system to employ alkoxyarene substrates bearing electron donating and withdrawing substituents is demonstrated. Addnl., ortho-substituted aryl ethers are well tolerated, overcoming the “ortho constraint”, which is the necessity to have a meta-substituent on the alkoxyarene to achieve high reaction efficiency, by enlisting novel norbornene mediators. Remarkably, for the first time the monoarylation of alkoxyarenes is achieved efficiently enabling the subsequent introduction of a second, different aryl coupling partner to rapidly furnish unsym. terphenyls. Further insight into the reaction mechanism was achieved by isolation and characterization of some Pd-complexes-before and after meta C-H activation-prior to evaluation of their resp. catalytic activities. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application In Synthesis of 2-Methylanisole

The Article related to biphenyl terphenyl alkoxy preparation, aryl ether regioselective arylation aryl halide palladium norbornene catalyst, arylation, c鈭抙 activation, ligand design, palladium, reaction mechanisms and other aspects.Application In Synthesis of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Hao; He, Xiaobo; Zhang, Yaqi; Chen, Bin; Ouyang, Jia-sheng; Li, Yongsu; Pan, Bendu; Subba Reddy, Chitreddy V.; Chan, Wesley Ting Kwok; Qiu, Liqin published an article in 2020, the title of the article was Copper-catalyzed (4+1) and (3+2) cyclizations of iodonium ylides with alkynes.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline And the article contains the following content:

The copper(II)-catalyzed (4+1) cyclizations and copper(I)-catalyzed (3+2) cycloadditions of iodonium ylides R(O)CC(=IC6H5)C(O)R1 [R = R1 = OMe, OEt, OCH2CF3; RR1 = -N(CH3)C(O)N(CH3)-] and 5-methyl-3-(2-phenylethynyl)pyridin-2-amine and alkynes 2-NHR2-4-R3-C6H3CCR4 (R2 = H, CH3; R3 = H, Cl; R4 = Ph, isoquinolin-4-yl, thiophen-2-yl, etc.) and 2-OH-4-R5-5-R6C6H2CCR4 (R5 = R6 = H, R5R6 = -CH=CH-CH=CH-) were successfully developed by employing efficient and safe iodonium ylides instead of traditional diazo compounds Highly functionalized di-Me (E)-3-benzylideneindoline-2,2-dicarboxylates I and II and Me 5-(2-hydroxyphenyl)-2-methoxy-4-phenylfuran-3-carboxylates III were conveniently prepared in moderate to excellent yields. The possible reaction mechanisms were also discussed. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

The Article related to dimethyl benzylideneindoline dicarboxylate preparation diastereoselective, methyl hydroxyphenyl methoxyphenylfuran carboxylate preparation, iodonium ylide alkyne cycloaddition copper catalyst and other aspects.Quality Control of 2-((4-Methoxyphenyl)ethynyl)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 30, 2021, Deng, Xiujuan; Huang, Ganghua; Tu, Qing; Zhou, Hongjie; Li, Yali; Shi, Hongyuan; Wu, Xianxue; Ren, Hongtao; Huang, Kunlun; He, Xiaoyun; Xu, Wentao published an article.COA of Formula: C8H10O2 The title of the article was Evolution analysis of flavor-active compounds during artificial fermentation of Pu-erh tea. And the article contained the following:

For the urgent need for fermentation control and product quality improvement of Pu-erh tea, gas chromatog.-mass spectrometry and odor activity value (OAV) were used to comprehensively investigate the flavor-active compounds during artificial fermentation of Pu-erh tea. A flavor wheel was constructed to expound the sensory attributes evolution during fermentation With an increased total volatiles content, 43 were significantly up-regulated and 30 were down-regulated among 131 detected volatiles. Key active compounds of three aroma types, namely fresh fragrance, fruit-fungus fragrance and stale-Qu fragrance, were analyzed based on OAV. 尾-damascenone was firstly found contributing most to the aroma of Pu-erh tea, followed by 1,2,3-methoxybenzene and (E,E)-2,4-nonadienal. 纬-terpinene, linalool, 1,2,4-trimethoxybenzene, 1,2,3-trimethoxybenzene, and 4-ethylveratrol were identified as the potential markers responsible for aroma differences among three fermentation stages. Finally the metabolic evolution of key flavor-active compounds were systematically summarized. This study provides significant guidance in fermentation control and new product development of Pu-erh tea. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).COA of Formula: C8H10O2

The Article related to betadamascenone gammaterpinene linalool artificial fermentation pu erh tea, aroma profile, artificial fermentation, flavor-active compounds, metabolic evolution, odor activity value, pu-erh tea and other aspects.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 31, 2019, Gobbi, Silvia; Hu, Qingzhong; Foschi, Giacomo; Catanzaro, Elena; Belluti, Federica; Rampa, Angela; Fimognari, Carmela; Hartmann, Rolf W.; Bisi, Alessandra published an article.Application In Synthesis of 1-Fluoro-2-methoxybenzene The title of the article was Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing. And the article contained the following:

The inhibition of steroidogenic cytochrome P 450 enzymes has been shown to play a central role in the management of life-threatening diseases such as cancer, and indeed potent inhibitors of CYP19 (aromatase) and CYP17 (17伪 hydroxylase/17,20 lyase) are currently used for the treatment of breast, ovarian and prostate cancer. In the last few decades CYP11B1 (11-尾-hydroxylase) and CYP11B2 (aldosterone synthase), key enzymes in the biosynthesis of cortisol and aldosterone, resp., have been also investigated as targets for the identification of new potent and selective agents for the treatment of Cushing’s syndrome, impaired wound healing and cardiovascular diseases. In an effort to improve activity and synthetic feasibility of our different series of xanthone-based CYP11B1 and CYP11B2 inhibitors, a small series of imidazolylmethylbenzophenone-based compounds, previously reported as CYP19 inhibitors, was also tested on these new targets, in order to explore the role of a more flexible scaffold for the inhibition of CYP11B1 and -B2 isoforms. Compound 3 proved to be very potent and selective towards CYP11B1, and was thus selected for further optimization via appropriate decoration of the scaffold, leading to new potent 4′-substituted derivatives In this second series, 4 and 8, carrying a methoxy group and a Ph ring, resp., proved to be low-nanomolar inhibitors of CYP11B1, despite a slight decrease in selectivity against CYP11B2. Moreover, unlike the benzophenones of the first series, the 4′-substituted derivatives also proved to be selective for CYP11B enzymes, showing very weak inhibition of CYP19 and CYP17. Notably, the promising result of a preliminary scratch test performed on compound 8 confirmed the potential of this compound as a wound-healing promoter. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application In Synthesis of 1-Fluoro-2-methoxybenzene

The Article related to benzophenone cyp11b1 cyp11b2 inhibitor wound healing cortisol steroidogenesis, benzophenone, cyp11b1 (11-尾-hydroxylase), cyp11b2 (aldosterone synthase), cortisol, steroidogenesis, wound healing and other aspects.Application In Synthesis of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 31, 2021, Trusiano, Giuseppe; Vitale, Alessandra; Bonneaud, Celine; Pugliese, Diego; Dalle Vacche, Sara; Joly-Duhamel, Christine; Friesen, Chadron M.; Bongiovanni, Roberta published an article.Quality Control of 2-(2-(Vinyloxy)ethoxy)ethanol The title of the article was Vinyl ethers and epoxides photoinduced copolymerization with perfluoropolyalkylether monomers. And the article contained the following:

New perfluoropolyalkylether (PFPAE) monomers, chain extended with different alkyl groups and functionalized with vinyl ether or epoxide end-groups, were employed, together with trimethylolpropane trivinyl ether or trimethylolpropane triglycidyl ether, to produce fluorinated copolymers. The photoinduced cationic polymerization was investigated, and the PFPAE-based copolymer properties were thoroughly characterized. Interesting surface properties and two different values of refractive index were observed: thus, these fluorinated copolymers can be suitable materials for the manufacture of self-cleaning coatings and optical waveguides. The experimental process involved the reaction of 2-(2-(Vinyloxy)ethoxy)ethanol(cas: 929-37-3).Quality Control of 2-(2-(Vinyloxy)ethoxy)ethanol

The Article related to perfluoropolyalkylether monomer vinyl ether epoxide photoinduced copolymerization thermal property, cationic polymerization, perfluoropolyalkylethers, refractive index, sliding angle, uv curing and other aspects.Quality Control of 2-(2-(Vinyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kaga, Atsushi; Hayashi, Hirohito; Hakamata, Hiroyuki; Oi, Miku; Uchiyama, Masanobu; Takita, Ryo; Chiba, Shunsuke published an article in 2017, the title of the article was Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite.Formula: C7H7FO And the article contains the following content:

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Formula: C7H7FO

The Article related to benzannulated nitrogen heterocycle preparation, methoxy arene amine nucleophilic amination, dft calculations, amination, nitrogen heterocycles, nucleophilic aromatic substitution, sodium hydride and other aspects.Formula: C7H7FO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 7, 2021, Yu, Tianliang; Wang, Youfu; Jiang, Kaiyue; Zhai, Guangqun; Ke, Changchun; Zhang, Jichao; Li, Jiantong; Tranca, Diana; Kymakis, Emmanuel; Zhuang, Xiaodong published an article.Reference of 1,2-Dimethoxybenzene The title of the article was Catechol-Coordinated Framework Film-based Micro-Supercapacitors with AC Line Filtering Performance. And the article contained the following:

Coordination polymer frameworks (CPFs) have broad applications due to their excellent features, including stable structure, intrinsic porosity, and others. However, preparation of thin-film CPFs for energy storage and conversion remains a challenge because of poor compatibility between conductive substrates and CPFs and crucial conditions for thin-film preparation In this work, a CPF film was prepared by the coordination of the anisotropic four-armed ligand and CuII at the liquid-liquid interface. Such film-based micro-supercapacitors (MSCs) are fabricated through high-energy scribing and electrolytes soaking. As-fabricated MSCs displayed high volumetric specific capacitance of 121.45 F cm-3. Besides, the volumetric energy d. of MSCs reached 52.6 mWh cm-3, which exceeds the electrochem. performance of most reported CPF-based MSCs. Especially, the device exhibited a.c. (AC) line filtering performance (-84.2掳 at 120 Hz) and a short resistance capacitance (RC) constant of 0.08 ms. This work not only provides a new CPF for MSCs with AC line filtering performance but also paves the way for thin-film CPFs preparation with versatile applications. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Reference of 1,2-Dimethoxybenzene

The Article related to copper catechol coordination polymer framework microsupercapacitor alternating current, alternating current line filtering, catechol, coordination polymer framework, copper, micro-supercapacitor and other aspects.Reference of 1,2-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem