Yoo, Kihyun published the artcileEnantioselective synthesis of (R)-tolterodine via CuH-catalyzed asymmetric conjugate reduction, Application of 2-Methoxy-5-methylphenylboronic acid, the main research area is tolterodine asym preparation; diarylacrylonitrile stereoselective preparation conjugate reduction copper reductive amination.
An efficient and highly enantioselective method for the preparation of (R)-tolterodine (I) is described. The synthesis was performed by CuH-catalyzed asym. conjugate reduction of a β,β-diaryl-substituted unsaturated nitrile as a key step, which is prepared by a stereoselective hydroarylation of alkynenitrile with aryl boronic acid. The synthesis was accomplished without employing the protection-deprotection sequence.
Journal of Organic Chemistry published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Application of 2-Methoxy-5-methylphenylboronic acid.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem