Yang, Xintong published the artcileEfficient synthesis of chiral biaryls via asymmetric Suzuki-Miyaura cross-coupling of ortho-bromo aryl triflates, Application In Synthesis of 127972-00-3, the main research area is biaryl preparation Suzuki coupling palladium benzoxaphosphole.
Efficient asym. Suzuki-Miyaura coupling of ortho-bromo aryl triflates with various arylboronic acids were described, providing a series of chiral biaryl triflates in high yields and up to 91% ee under mild conditions. The aryl triflates could be easily transformed to various chiral biaryl products by further derivatization. A one-pot tandem asym. cross-coupling/cross-coupling sequence was also achieved by using a single palladium catalyst, demonstrating the versatility of this method for preparation of chiral biaryl products. Under optimized conditions the synthesis of the target compounds was achieved using palladium(II) acetate and (2S,3S)-4-(2,6-dimethoxyphenyl)-3-(1,1-dimethylethyl)-2,3-dihydro-2-methyl-1,3-benzoxaphosphole as catalyst and ligand combination. Starting materials included 1,1,1-trifluoromethanesulfonic acid 1-bromo-2-naphthalenyl ester and B-(9-phenanthrenyl)boronic acid, B-(5-pyrenyl)boronic acid, B-(1,2-dihydro-5-acenaphthylenyl)boronic acid, B-[[1,1′-biphenyl]-2-yl]boronic acid, B-(2-formylphenyl)boronic acid. The title compounds thus formed included chiral biaryl derivatives, such as 1,1,1-trifluoromethanesulfonic acid, (1S)-[1,1′-binaphthalen]-2-yl ester.
Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Application In Synthesis of 127972-00-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem