Wang, Lin published the artcileEstablishment of a lung cancer discriminative model based on an optimized support vector machine algorithm and study of key targets of wogonin in lung cancer, Synthetic Route of 121-00-6, the main research area is lung cancer wogonin support vector machine algorithm; SVM; key targets; lung cancer; network pharmacology; serum index; wogonin.
An optimized support vector machine model was used to construct a lung cancer diagnosis model based on serol. indicators, and a mol. regulation model of Wogonin, a component of Scutellaria baicalensis, was established. Serol. indexes of patients were collected, the grid search method was used to identify the optimal penalty coefficient C and parameter g of the support vector machine model, and the benign and malignant auxiliary diagnosis model of isolated pulmonary nodules based on serol. indicators was established. The regulatory network and key targets of Wogonin in lung cancer were analyzed by network pharmacol., and key targets were detected by western blot. The relationship between serol. susceptibility genes and key targets of Wogonin was established, and the signaling pathway of Wogonin regulating lung cancer was constructed. After support vector machine parameter optimization (C = 90.597, g = 32), the accuracy of the model was 90.8333%, with nine false positives and two false neg. cases. Ontol. functional anal. of 67 common genes between Wogonin targets and lung cancer-related genes showed that the targets were associated with biol. processes involved in peptidye-serine modification and regulation of protein kinase B signaling; cell components in the membrane raft and chromosomal region; and mol. function in protein serine/threonine kinase activity and heme binding. Kyoto Encyclopedia of Genes and Genomes anal. showed that the regulation pathways involved the PI3K-Akt signaling pathway, ERBB signaling pathway, and EGFR tyrosine kinase inhibitor resistance. In vitro analyses using lung cancer cells showed that Wogonin led to significantly increased levels of cleaved caspase-3 and Bad and significantly decreased Bcl-2 expression in a concentration-dependent manner. ErbB4 expression also significantly decreased in lung cancer cells after treatment with Wogonin. A regulatory network of Wogonin regulating lung cancer cell apoptosis was constructed, including the participation of serol. susceptibility genes. There is a certain regulatory effect between the serol. indexes that can be used in the diagnosis of lung cancer and the key targets of Chinese herbal medicine treatment of lung cancer, which provides a new idea for the diagnosis, treatment and prognosis of clin. lung cancer.
Frontiers in Pharmacology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (YAP). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Synthetic Route of 121-00-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem