Sonda, Shuji published the artcileSynthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT4 receptor agonists, Formula: C8H9ClO, the main research area is piperidinylmethylamine benzoic acid amidation; benzamide derivative preparation 5HT4 ligand; piperidinylmethyl benzamide stereoselective preparation 5HT4 ligand.
It is thought that selective 5-HT4 receptor agonists-such as 4-amino-5-chloro-2-methoxy-N-[1-(6-oxo-6-phenylhexyl)piperidin-4-ylmethyl]benzamide (I)-have the ability to enhance both upper and lower gastrointestinal motility without any significant adverse effects. Modification of I was performed. Variation of the piperidin-4-ylmethyl moiety of I led to a decrease in the binding affinity for the 5-HT4 receptor. Following conversion of the carbonyl group on the benzoyl part to a hydroxyl or sulfoxide group, the binding affinity for the 5-HT4 receptor was retained although the effect on defecation was reduced. Many of the 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamides that had a ether or sulfide moiety in the side-chain part at the 1-position of the piperidine exhibited high affinity for the 5-HT4 receptor. Two of the compounds were selective 5-HT4 receptor agonists, and had a similar effect on defecation to I.
Bioorganic & Medicinal Chemistry published new progress about 5-HT4 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Formula: C8H9ClO.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem