Soltani Rad, Mohammad Navid published the artcileDesign and Synthesis of Some Novel Oxiconazole-Like Carboacyclic Nucleoside Analogues, as Potential Chemotherapeutic Agents, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is carboacyclic nucleoside oxiconazole stereoselective preparation; nucleobase alkyl halide nucleophilic substitution oximation alkylation; formation heat calculation PM3 stereoselectivity.
The synthesis of some novel carboacyclic nucleosides containing oxiconazole-like scaffolds, e.g. I, is described. In this series of carboacyclic nucleosides, pyrimidine as well as purine and other imidazole derivatives were employed as an imidazole successor in oxiconazole. These compounds could be prepared in good yields by using two different strategies. The first strategy uses N-coupling of nucleobases with 2-bromoacetophenones, followed by subsequent oximation and finally O-alkylation with diverse alkylating sources. The second strategy uses N-coupling of 2-bromoacetophenone oximes with nucleobases, followed by O-alkylation. For the rational interpretation of the dominant formation of (E)-oxime ethers rather than (Z)-oxime isomers, PM3 semiempirical quantum-mechanic calculations were discussed and the calculations indicated a lower heat of formation for (E)-isomers.
Helvetica Chimica Acta published new progress about Alkylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem