Salteris, Constantinos S. published the artcileOrtho-directed lithiation of ω-phenoxyalkanethiols and N,N-dimethyl-ω-phenoxyalkylamines. Crystal structure of bis[o-[(2-dimethylamino)ethoxy]phenyl]mercury, Safety of (2-Chloroethoxy)benzene, the main research area is crystal mol structure mercury aminoethoxyphenyl preparation; ortho lithiation phenoxyalkanethiol phenoxyalkylamine.
ω-Phenoxyalkanethiols, PhO(CH2)nSH (n = 2-6) were prepared and ortho-metalated with two equiv BuLi in THF/methylcyclohexane. Carboxylation and subsequent acidic hydrolysis of the resulting dilithiated species yielded the corresponding o-(ω-mercaptoalkoxy)benzoic acids in 30-78% yields%. The previously reported methodol. for the ortho-lithiation of (2-dimethylamino)ethoxy-benzene by BuLi in ether was extended to higher members of this class, PhO(CH2)nNMe2 with n = 2-4. The resulting organolithiums react normally with electrophilic reagents, benzaldehyde (n = 2-4), benzophenone (n = 2-4) and dichlorodiphenylsilane (n = 2) in yields of 63-77%; reaction with 0.5 molar equiv of mercuric dichloride (n = 2) afforded the bis[o-[(2-dimethylamino)ethoxy]phenyl]mercury in a 78% yield, the crystal structure of which was determined
Main Group Metal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent) (phenoxyalkylamines). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Safety of (2-Chloroethoxy)benzene.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem