Pittala, Valeria published the artcileSynthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors, SDS of cas: 622-86-6, the main research area is synthesis pyrrolo pyrimidine dione derivative alpha 1 adrenoceptor.
Three different series of 1H-pyrrolopyrimidine-2,4-dione derivatives were designed and synthesized as ligands for the α1-adrenergic receptors (α1-ARs). A microwave-assisted protocol was developed in order to improve purity and yields of some final products. The majority of the synthesized compounds, tested in binding assays, displayed α1-AR affinities in the nanomolar range. Highest affinity values were found in derivatives 10b and 10c (K i = 1.4 nM for both) whereas compound 10e was endowed with the best profile in term of α1-AR affinity (K i = 2.71 nM) coupled with high selectivity towards 5-HT1A receptors (K i >10,000). Mol. docking studies were performed on human α1-ARs and human 5-HT1A receptors in order to rationalize the observed exptl. affinity and selectivity; these computational studies helped to clarify mol. requirements for the design of high-selective α1-adrenergic ligands.
Bioorganic & Medicinal Chemistry published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem