Pais, Adi published the artcileIn Vivo Magnetic Resonance Imaging of the Estrogen Receptor in an Orthotopic Model of Human Breast Cancer, Name: (2-Chloroethoxy)benzene, the main research area is magnetic resonance imaging contrast agent estrogen receptor breast cancer.
Histol. overexpression of the estrogen receptor α (ER) is a well-established prognostic marker in breast cancer. Noninvasive imaging techniques that could detect ER overexpression would be useful in a variety of settings where patients’ biopsies are problematic to obtain. This study focused on developing, by in vivo MRI, strategies to measure the level of ER expression in an orthotopic mouse model of human breast cancer. Specifically, novel ER-targeted contrast agents based on pyridine-tetra-acetate-Gd(III) chelate (PTA-Gd) conjugated to 17β-estradiol (EPTA-Gd) or to tamoxifen (TPTA-Gd) were examined in ER-pos. or ER-neg. tumors. Detection of specific interactions of EPTA-Gd with ER were documented that could differentiate ER-pos. and ER-neg. tumors. In vivo competition experiments confirmed that the enhanced detection capability of EPTA-Gd was based specifically on ER targeting. In contrast, PTA-Gd acted as an extracellular probe that enhanced ER detection similarly in either tumor type, confirming a similar vascular perfusion efficiency in ER-pos. and ER-neg. tumors in the model. Finally, TPTA-Gd accumulated selectively in muscle and could not preferentially identify ER-pos. tumors. Together, these results define a novel MRI probe that can permit selective noninvasive imaging of ER-pos. tumors in vivo. Cancer Res; 71(24); 7387-97.
Cancer Research published new progress about Estrogen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem