Lowicki, Daniel published the artcileStereoselective protonation of 2-methyl-1-tetralone lithium enolate catalyzed by salan-type diamines, Related Products of ethers-buliding-blocks, the main research area is methyl tetralone preparation enantioselective DFT; methyltetralone lithium enolate protonation chiral amine catalyst.
An efficient enantioselective protonation of 2-methyl-1-tetralone lithium enolate catalyzed by salan-type diamines I (Y = H, Me; X = H, OH, OMe; Z = t-Bu, H, NO2, Br, OMe; R = H, t-Bu, triphenylmethyl) and IInod t-bu was reported. A broad series of salan-type catalysts I and II was synthesized, including several previously unknown, and subsequently tested in the title reaction. For the first time, a chiral amine I and II used as organocatalyst has shown better results than as stoichiometric protonating agent. Application of only 10 mol% of salan I and II allows to obtain the (S)-2-methyl-1-tetralone with high yield and enantiomeric excess up to 75%. The DFT calculations of the structure of the catalyst and its complex with lithium enolate were conducted, which makes it possible to propose a likely reaction mechanism.
Tetrahedron published new progress about Cyclohexanes Role: CAT (Catalyst Use), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Related Products of ethers-buliding-blocks.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem