Gupta, Ramesh C. published the artcileNovel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor, Category: ethers-buliding-blocks, the main research area is piperidine cyanothiazolidinoylmethyl hydrazino derivative preparation dipeptidyl peptidase inhibition activity; hydrazinopiperidine DPPIV inhibitor structure activity relationship insulin release stimulator.
A novel class of N-substituted 4-hydrazino piperidine derivatives containing chiral cyanothiazolidinoyl moieties were designed, synthesized and evaluated for DPP IV inhibition. The SAR studies on the N-substituted piperidines led to the discovery of compound I as a potent DPP IV inhibitor (IC50 88 nM), which is highly selective over other peptidases. In vivo efficacy indicates that compound I stimulates insulin release in response to glucose load and improves glucose tolerance in n5-STZ and Zucker Diabetic Fatty (ZDF) rats.
Bioorganic & Medicinal Chemistry Letters published new progress about Hydrazines Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem