Eastman, Brian published the artcileExpedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology, SDS of cas: 127972-00-3, the main research area is phenyltetrazolyl pyridine preparation mGluR5 antagonist structure.
The SAR of the lead compounds I (R = H) and I (R = F) was rapidly explored. Utilizing a parallel solution-phase Suzuki coupling approach, in tandem with strong cation exchange resin (SCX) purification afforded the desired focused library. The library was evaluated in vitro, a ninefold potency increase was achieved and the preference for ortho substitution of moderate steric bulk of the fourth, Ph ring was identified. In addition, dimethylisoxazole, as a heterocyclic replacement for the phenylic ring of the lead compound, was also identified by this approach.
Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem