Cai, Shou-Le published the artcileNHC Ligand-Enabled, Palladium-Catalyzed Non-Directed C(sp3)-H Carbonylation To Access Indanone Cores, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is indanone preparation NHC ligand palladium catalyst; aryl triflate bromide carbon monoxide carbonylation.
A palladium-catalyzed C(sp3)-H carbonylation of alkylated aryl triflates or bromides I (R1 = 6-C6H5, 6-CH3CO, 6-CO2CH3, etc.; R2 = CH3, CO2CH3, CH2CH3, etc.; X = Br, OTf, ONf) under 1 atm of CO has been developed, in which no directing group or oxidant was required. The essence of this reaction is the combination of appropriate NHC ligands with palladium to facilitate the formation of the five-membered cyclopalladium intermediate. Mechanism studies suggest that the insertion of carbon monoxide into two five-membered cyclopalladium species generated via palladium migration might be the crucial step for this transformation. This method offers an efficient solution for expedient construction of indanone cores II (R1 = 6-C6H5, 6-CH3CO, 6-CO2CH3, etc.; R2 = CH3, CO2CH3, CH2CH3, etc.) which are valuable synthons and pharmacophores ubiquitously found in numerous natural products.
ACS Catalysis published new progress about Aryl triflates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkyl). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem