Blackburn, Karen L. published the artcileAn interim internal Threshold of Toxicologic Concern (iTTC) for chemicals in consumer products, with support from an automated assessment of ToxCast dose response data, Application In Synthesis of 121-00-6, the main research area is chem consumer product ToxCast dose response assessment; High throughput screening data analysis; Risk assessment; SAR; Structure activity relationships; TTC; Threshold of toxicological concern; ToxCast.
Addnl. non-animal methods are urgently needed to meet regulatory and animal welfare goals. TTC is a broadly used risk assessment tool. TTC based on external dose has limited utility for multi-route exposure and some types of structure activity relationship assessments. An internal TTC (iTTC), where thresholds are based on blood concentration, would extend the applicability of TTC. While work is on-going to develop robust iTTC thresholds, we propose an interim conservative iTTC. Specifically, an interim iTTC of 1μM, supported by the published experience of the pharmaceutical industry, a literature review of non-drug chem./receptor interactions, and anal. of ToxCast data. ToxCast data were used to explore activity vs. the 1μM interim iTTC and recommendations for the anal. and interpretation of HTS data. Test concentration-based points of departure were classified to identify quality of fit to the Hill Model. We identified, for exclusion from the approach, estrogen receptor and androgen receptor targets as potent chem./receptor interactions potentially associated with low dose exposure to non-pharmaceutical active ingredients in addition to the original TTC exclusions. With these exclusions, we conclude that a 1μM plasma concentration is unlikely to be associated with significant biol. effects from chems. not intentionally designed for biol. activity.
Regulatory Toxicology and Pharmacology published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Application In Synthesis of 121-00-6.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem