Beller, Matthias published the artcilePalladium-catalyzed reactions for fine chemical synthesis, Part 6. Efficient chemoenzymic synthesis of enantiomerically pure α-amino acids, Recommanded Product: 2-Methoxyacetamide, the main research area is amino acid asym chemoenzymic synthesis; amidocarbonylation aldehyde amino acid preparation; enzymic hydrolysis acylamino acid.
A general two-step chemoenzymic synthesis for enantiomerically pure natural and nonnatural α-amino acids is presented. In the first step of the sequence, the ubiquitous educts aldehyde, amide and carbon monoxide react by palladium-catalyzed amidocarbonylation to afford the racemic N-acyl amino acids in excellent yields. In the second step, enzymic enantioselective hydrolysis yields the free optically pure α-amino acid and the other enantiomer as the N-acyl derivative, both in optical purities of 85-99.5% ee. The advantage of the chemoenzymic process compared to other amino acid synthesis are demonstrated by the preparation of various functionalized (-OR, -Cl, -F, -SR) α-amino acids on a 10-g scale.
Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 16332-06-2 belongs to class ethers-buliding-blocks, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Recommanded Product: 2-Methoxyacetamide.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem