Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions was written by Zhu, Xiancui;Xu, Mengchen;Sun, Jinrong;Guo, Dianjun;Zhang, Yiwei;Zhou, Shuangliu;Wang, Shaowu. And the article was included in European Journal of Organic Chemistry in 2021.Application In Synthesis of 2-Methoxyethylamine The following contents are mentioned in the article:
Sym. and unsym. N,N’-disubstituted as well as trisubstituted ureas/thioureas R1NHC(X)N(R2)R3 (R1 = Ph, t-Bu, cyclohexyl, etc.; R2 = Ph, t-Bu, furan-2-ylmethyl, etc.; R3 = H, Me; R2R3 = morpholin-4-yl, piperidin-1-yl; X = O, S) by the hydroamination of isocyanates/isothiocyanates R1N=C=X, and various phosphathioureas R1NHC(S)PPh2 by the hydrophosphination of isothiocyanates R1N=C=S have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas/thioureas e.g., (S)-1-(1-phenylethyl)-3-(p-tolyl)urea and common herbicides, such as fenuron and monuron. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application In Synthesis of 2-Methoxyethylamine).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of 2-Methoxyethylamine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem