Formation of N-P(O)-S Bonds from White Phosphorus via a Four-Component Reaction was written by Zhang, Yue;Cao, Yinwei;Chi, Yangyang;Chen, Shuanghui;Zeng, Xiangzhe;Liu, Yan;Tang, Guo;Zhao, Yufen. And the article was included in Advanced Synthesis & Catalysis in 2022.Synthetic Route of C3H9NO The following contents are mentioned in the article:
Functionalization of white phosphorus with disulfides ArSSAr (Ar = Ph, 2-fluorophenyl, 4-methylphenyl, etc.), amines R1NHR2 [R1 = Et, cyclohexyl, furan-2-ylmethyl, etc.; R2 = H, Me, Et, n-butyl; R1R2 = -(CH2)4-, -(CH2)6-, -(CH2)2O(CH2)2-, etc.] and KOH to phosphoramidodithioates P(O)(ArS)2NR1R2 containing both P-N, P-S and P=O bonds via a four-component reaction is presented. It proceeds with high yields and provides an attractive approach for the construction of valuable N-P(O)-S motif using a one-step strategy. The advantages of this newly developed process include a clean reaction profile, complete conversion of white phosphorus, transition metal-free and halogen-free environmentally benign system, and large-scale synthetic application. Besides, phosphoramidodithioates can also be utilized to construct P-C, P-O and P=S bonds with the appropriate reagents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C3H9NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem