Discovery of 5-methylpyrimidopyridone analogues as selective antimycobacterial agents was written by Wu, Yu;Cheung, Chen-Yi;Zhou, Yang;Wang, Zhen;Tu, Zhengchao;Cook, Gregory M.;Lu, Xiaoyun. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:
With the emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and extensive drug-resistant strains (XDR-TB), there is an urgent need to develop novel drugs for the treatment of tuberculosis. Here, the authors designed and synthesized a series of 5-methylpyrimidopyridone analogs I [R1 = NHEt, cyclopropylamino, 4-methylpiperidino, etc., R2 = (3s,5S,7s)-adamant-1-yl, cyclopentyl, cyclohexyl, R3 = 2-Cl, 4-Cl, H, 2-CN, etc.] as potential antitubercular agents. The most potent compound II exhibited a MIC value of 4μM in vitro against Mycobacterium tuberculosis. The antitubercular activities of the synthesized compounds were impacted by the amantadine and 2-chlorophenyl groups, and were enhanced by the presence of 3-methyl(4-dimethylamino)piperidinylphenyl. Mol. modeling and binding studies suggest that PknB is the potential mol. target of 5-methylpyrimidopyridone compounds This study provides insights for the future development of new antimycobacterial agents with novel mechanisms of action. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C3H9NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem