Cu(I)-Catalyzed [2 + 2 + 1] Cycloaddition of Amines, Alkynes, and Ketenes: An Umpolung and Regioselective Approach to Full-Substituted β-Pyrrolinones was written by Wu, Hao;Li, Xinyao;Yan, Zixi;Ma, Nana;Song, Song;Zhang, Guisheng;Jiao, Ning. And the article was included in Organic Letters in 2021.Application of 109-85-3 The following contents are mentioned in the article:
Described here is a Cu-catalyzed [2 + 2 + 1] modular synthesis of full-substituted β-pyrrolinones I [R1 = Bu, 2,6-dimethylphenyl, benzyl, etc.; R2 = Me, Et, t-Bu, benzyl; R3 = Me, Et; E1 = C(O)OMe, C2F5, CF3] and II [E2 = Me, Et; R4 = C(O)OMe, Ph, Me, Bn; R5 = 4-methoxyphenyl, 4-(methylcarbonyl)phenyl, (4-bromophenyl)methyl, 2-phenylethyl] from simple amines R1NH2, alkynes E1CCC(O)OCH3, and α-diazo-β-ketoesters R3C(O)C(=N2)C(O)OR2 or enamines E2O(O)CCH=C(R4)NHR5 with Et 2-diazo-3-oxobutanoate. This approach involving the regioselective C-nucleophilic attack of enamines, uncommon C-nucleophilic addition to ketenes, and umpolung of imines enables the direct synthesis of full-substituted β-pyrrolinones II, which were hardly constructed by traditional synthetic strategies. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem