Remote Site-Selective Radical C(sp3)-H Monodeuteration of Amides using D2O was written by Wang, Lin;Xia, Yong;Derdau, Volker;Studer, Armido. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 109-85-3 The following contents are mentioned in the article:
Site-selective incorporation of deuterium into biol. active compounds is of high interest in pharmaceutical industry. A mild and environmentally benign metal-free method for the remote selective radical C-H monodeuteration of aliphatic C-H bonds in various amides with inexpensive heavy water (D2O) as the deuterium source were presented. The method uses the easily installed N-allylsulfonyl moiety as an N-radical precursor that generates the remote C-radical via site-selective 1,5- or 1,6-hydrogen atom transfer (HAT). Me thioglycolate, that readily exchanges its proton with D2O, serves as the radical deuteration reagent and as a chain-carrier. The highly site-selective monodeuteration was applied to different types of unactivated sp3-C-H bonds and also to the deuteration of C-H bonds next to heteroatoms. The potential utility of this method was further demonstrated by the site-selective incorporation of deuterium into natural product derivatives and drugs. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Product Details of 109-85-3).
2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 109-85-3
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem